About 19 years ago I would stay at a particular hotel whenever I would be in town and became friendly with the hotel staff. They informed me of which rooms were better than the others and would give me a little extra room amenities, and would inform me of their sanitary practices.
I would sometimes arrive during the time that the rooms were being cleaned and noticed that no one had a comforter on their carts. So I began to ask if the comforters are changed after each guest and was told no, however, if I wanted a clean one, someone would bring it to me. I later saw a documentary on the cleanliness of hotels and was shocked. I can't remember the exact tineframe, but one housekeeper told me that whenever she travels, she always removes the bedding and will replace it with her own. I also read that someone else never touch the remote for the entire stay.
Whenever, I enter the room I will spray lysol on the remote and the toilet seat. Since I have been staying at Marriott's, I have not seen the heavy comforter, and they use the duvet instead, which are on the housekeepers cart. I have stayed at three other brands and they also had the duvet covers, do maybe the hospitality industry decided on a change.
What is the first thing that you do after you enter your room and does it depend if you are traveling with your family?